Are you tired all the time?
That is not being lazy. It has a name: idiopathic hypersomnia, or IH. “Idiopathic” means doctors do not know what causes it yet. A research study called ONSTRIDE-2 is now enrolling adults 18 and older who live with it — run right here by the sleep doctors at Sleep and Attention Disorders Institute.
- The check takes about 2 minutes. There is no cost, and no pressure to join.
- Study medicine and all study visits are free.
- Most visits happen in person at our clinic.
People who join are paid for their time and travel. Some patients earn up to $1,700 for completing the study, with the potential for more if they continue into the optional extension.
2-minute check
Apply for the study
Answer a few questions and we will tell you if you may be a fit for the ONSTRIDE-2 study. This is not the full list of requirements — the study doctor goes through all of them with you before anything is decided. Answering does not sign you up for anything.
Want to see the questions before you answer them? Open the printable question sheet (PDF) — handy if you want to go over them with your own doctor first.
Does this sound like you?
Everyone told you to go to bed earlier. You did. It did not help.
Idiopathic hypersomnia is a brain and sleep condition. Your body sleeps plenty. Your brain still runs on empty. It is not in your head, and it is not a habit you can fix by trying harder.
If you have been told you have IH and this is your normal week, the ONSTRIDE-2 study may be worth a look. Checking takes about two minutes, and it does not commit you to anything.
See If You QualifyAbout the study
So what is the ONSTRIDE-2 study, in plain words?
Doctors are testing a once-a-day tablet called HBS-301 to see if it helps adults with idiopathic hypersomnia. The study looks at whether it is safe, and whether it helps with the sleepiness and the heavy morning fog.
Right now there are not many options for IH. The medicines that exist do not work for everyone, and some people get side effects they do not want. That is the reason studies like this one exist — to find out if something better is possible.
The study is paid for by Harmony Biosciences and run near you by the team at Sleep and Attention Disorders Institute, where the doctors caring for you are sleep specialists. A safety board of doctors and experts reviewed this study before a single person joined.
See If You Qualify- How long it lasts
- About 16 weeks
- Time taking study medicine
- 8 weeks
- Check-ins by phone or video
- Once a week
- Optional extra period, if you want it
- 1 year
Never done a study before?
What you get
Here is exactly what taking part includes
Joining is your choice, and it stays your choice. You can say no now, and you can leave the study later at any point, for any reason, with nothing owed.
You get paid for this study.
No bill for any visit, test, or procedure that is part of the study. No insurance needed.Payment for time and travel may reach up to $1,700, based on the visits and procedures your part of the study requires. Payment is for your time — it is not a benefit of the study medicine.
The study medicine costs you nothing
Whether you get HBS-301 or the placebo, you never pay for it.
A sleep team watching over you
You check in with the study team every week during the treatment period. Somebody is actually paying attention to your sleep.
You are paid for your time and travel
People who take part are paid for the time and travel the study asks of them. Help with meals and a place to stay may also be available. Your study coordinator will go over the exact amounts with you.
You help move IH research forward
Every option doctors have today exists because people volunteered first. You would be part of the next one.
An optional extra year, if you want it
After the main part ends, you may be able to keep going for about a year. In that part, everyone takes HBS-301 — nobody gets the placebo.
Payment for time and travel may reach up to $1,700 per week, based on the visits and procedures your part of the study requires. Payment is for your time — it is not a benefit of the study medicine.
Who can join
Three things decide if you are a fit
You are 18 or older
The study is for adults only.
A doctor told you that you have IH
You need a diagnosis of idiopathic hypersomnia from a health care provider. If you don't have this, please make an appointment with us today.
You still live with the symptoms
Sleepy through the day, brutal mornings, or a fog that will not lift.
This is not the full list. The study doctor goes through every requirement with you before anything is decided. The fastest way to find out where you stand is the two-minute check below.
Take the 2-Minute CheckWhat actually happens
Here is the whole thing, start to finish
About 16 weeks in total — unless you choose to stay on for the optional extra year. Most of it happens from your couch, by phone or video.
- 1Up to 28 days
First, they check you out
Tests and questions to make sure the study is a safe fit for you. If it is not, you find out here, and you owe nothing.
- 28 weeks
Then you take the tablets
One tablet each morning — either HBS-301 or a placebo, picked at random. Neither you nor the study team knows which one you have. You check in every week by phone or video so the team can watch your health.
- 3About 30 days
Then two check-ins after
Two more calls or video visits, about 15 and 30 days after your last tablet, to see how you are doing.
- 4About 1 year · your choice
Then an extra year, if you want
If you qualify and choose to keep going, everyone in this part takes HBS-301 — no placebo. Check-ins are monthly by phone or video, plus 4 visits to the clinic across the year.
Some visits include blood tests, heart tests, a physical exam, or questionnaires. If you take certain other medicines, your dose may be adjusted. The study team explains every step before it happens.
Not ready to talk to anyone yet? Read it all first.
Take the brochure. It lays out the study the way you would want it explained — no jargon, nothing buried. Read it tonight, sit on it, and decide later. There is no cost and no obligation.
Download the Free BrochurePrefer a paper copy in the mail? Call (586) 254-0707 and we will send one.
- What is inside
- What a clinical study is, and what a study medicine is
- Why the ONSTRIDE-2 study is being done, and what it is testing
- All 6 requirements to join, spelled out
- The full schedule, period by period, with a timeline chart
- What it costs you, the risks involved, and how to leave
Straight answers
The questions everybody asks first
Got a question that is not here? Ask us. There is no pressure to join and no sales pitch waiting on the other end.
Talk to the Research TeamContact us
Rather just talk to a person?
Call, email, or stop by. We will answer whatever you want to ask, and you are under no obligation to join anything.
- (586) 254-0707
- austinj@sleepandattentiondisorders.com
- 44344 Dequindre Rd #360, Sterling Heights, MI 48314
- Monday – Friday, 8:00 AM – 5:00 PM
